Association of HLA-DRB1/DQB1 Alleles and Genetic Susceptibility to Type 1 Diabetes Mellitus

Objective: This study was conducted to identify the association of HLA-DRB1/DQB1 genes with susceptibility or resistance type 1 diabetes mellitus (T1D) among patients between ages five and eighteen. Subjects Methods: The included 200 Sudanese participants, ranging from 5 18. One hundred participants were healthy non-diabetic as control group 100 T1D case group. investigation carried out in Khartoum state. selection diabetic centers hospitals. allele-specific-refractory mutation system-polymerase chain reaction (ARMS-PCR) technique applied HLA gene polymorphism. Results: There a significant difference genotype frequency across groups current (Kruskal-Wallis, p-value= 0.021). Whereas CG not substantially different (Chi-square, p-value=0.116), CC considerably greater (46.0%) (Chi-square Adjusted p-value0.001). Conclusion: found that patients' genotypes allele frequencies are significantly correlated when compared those participants.